Bioavailability of immediate and controlled release formulations of lithium carbonate

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منابع مشابه

Bioavailability of immediate and controlled release formulations of lithium carbonate Biodisponibilidade de formulações de liberação imediata e controlada de carbonato de lítio

Sponsored by the CNPq (Processes ns. 132203/98-7 and 301596/79-4 – National Research Council Master and Researcher I Grants) and from the Association Fund of Incentive to Psychopharmacology (AFIP). Part of the Master thesis “Study on the Bioavailability and Chronobiology of Lithium in Healthy Volunteers”, presented to the Department of Psychobiology of the Unifesp/EPM, 2000. This study was part...

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Comparative pharmacokinetics and bioavailability of tapentadol following oral administration of immediate- and prolonged-release formulations.

OBJECTIVE To evaluate the bioavailability and pharmacokinetics of orally administered tapentadol immediate release (IR) compared with tapentadol prolonged release (PR). METHODS Three randomized, open-label, crossover studies were conducted in subjects under fasted conditions. Studies 1 and 2 determined the absolute bioavailability and pharmacokinetics of oral tapentadol IR 86 mg and tapentado...

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Slow drug delivery decreased total body clearance and altered bioavailability of immediate- and controlled-release oxycodone formulations.

Oxycodone is a commonly used analgesic with a large body of pharmacokinetic data from various immediate-release or controlled-release formulations, under different administration routes, and in diverse populations. Longer terminal half-lives from extravascular administration as compared to IV administration have been attributed to flip-flop pharmacokinetics with the rate constant of absorption ...

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Controlled Release Gel Formulations

Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermoreversible poloxamer gels, which are suitable for novel drug delivery applications. In particular co-solvents (DMSO, ethanol), mucoadhesive polymers (chitosan, alginate) and salt...

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Preparation and Evaluation of Waxes/Fat Microspheres Loaded with Lithium Carbonate for Controlled Release

To minimize the unwanted toxic effects of anti maniac drug lithium carbonate by kinetic control of drug release, it was entrapped into gastro resistant, biodegradable, waxes and fat such as beeswax, cetostearyl alcohol, spermaceti and cetylalcohol microspheres using meltable emulsified dispersion cooling induced solidification technique utilizing a wetting agent. Solid, discrete, reproducible f...

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ژورنال

عنوان ژورنال: Revista Brasileira de Psiquiatria

سال: 2002

ISSN: 1516-4446

DOI: 10.1590/s1516-44462002000200007